Mutational spectrometry: a general approach for hot-spot point mutations in selectable genes.
To observe point mutational spectra with a high degree of precision, independent large cultures of human lymphoblastoid cells were treated with a mutagen, benzo[a]pyrene diol epoxide, and mutants at the HPRT gene were selected en masse by 6-thioguanine resistance. An average of 1.6 x 10(4) 6-thiogua...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
1992
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC49135/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1584799/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.10.4623 |
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