Rare coding TTN variants are associated with electrocardiographic QT interval in the general population

We have shown previously that noncoding variants mapping around a specific set of 170 genes encoding cardiomyocyte intercalated disc (ID) proteins are more enriched for associations with QT interval than observed for genome-wide comparisons. At a false discovery rate (FDR) of 5%, we had identified 2...

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Udgivet i:Sci Rep
Main Authors: Kapoor, Ashish, Bakshy, Kiranmayee, Xu, Linda, Nandakumar, Priyanka, Lee, Dongwon, Boerwinkle, Eric, Grove, Megan L., Arking, Dan E., Chakravarti, Aravinda
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4913250/
https://ncbi.nlm.nih.gov/pubmed/27321809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28356
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