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Multiple SCN5A variant enhancers modulate its cardiac gene expression and the QT interval
The rationale for genome-wide association study (GWAS) results is sequence variation in cis-regulatory elements (CREs) modulating a target gene’s expression as the major cause of trait variation. To understand the complete molecular landscape of one of these GWAS loci, we performed in vitro reporter...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6561183/ https://ncbi.nlm.nih.gov/pubmed/31068470 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1808734116 |
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