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Comparative Pathobiology of Aβ and the Unique Susceptibility of Humans to Alzheimer's Disease

The misfolding and accumulation of the protein fragment Aβ is an early and essential event in the pathogenesis of Alzheimer's disease (AD). Despite close biological similarities among primates, humans appear to be uniquely susceptible to the profound neurodegeneration and dementia that characte...

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Detalhes bibliográficos
Publicado no:Neurobiol Aging
Main Authors: Rosen, Rebecca F., Tomidokoro, Yasushi, Farberg, Aaron S., Dooyema, Jeromy, Ciliax, Brian, Preuss, Todd M., Neubert, Thomas A., Ghiso, Jorge A., LeVine, Harry, Walker, Lary C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4913040/
https://ncbi.nlm.nih.gov/pubmed/27318146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2016.04.019
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