Tumor Necrosis Factor-Like Weak Inducer of Apoptosis Accelerates the Progression of Renal Fibrosis in Lupus Nephritis by Activating SMAD and p38 MAPK in TGF-β1 Signaling Pathway

This study aim was to explore the effects of tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in lupus nephritis and its potential underlying mechanisms. MRL/lpr mice were used for in vivo experiments and human proximal tubular cells (HK2 cells) were used for in vitro experiments. Result...

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Detalhes bibliográficos
Publicado no:Mediators Inflamm
Main Authors: Liu, Zhiqin, Xue, Leixi, Liu, Zhichun, Huang, Jun, Wen, Jian, Hu, Ji, Bo, Lin, Yang, Ru
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4913011/
https://ncbi.nlm.nih.gov/pubmed/27365897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/8986451
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