Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells

Targeting tumour-initiating cells (TICs) would lead to new therapies to cure cancer. We previously demonstrated that TICs have the capacity to survive under suspension conditions, while other cells undergo anoikis. Here we show that TICs exhibit increased phosphorylation levels of S727STAT3 because...

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Publicat a:Nat Commun
Autors principals: Liu, Chen-Chi, Lin, Shih-Pei, Hsu, Han-Shui, Yang, Shung-Haur, Lin, Chiu-Hua, Yang, Muh-Hwa, Hung, Mien-Chie, Hung, Shih-Chieh
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4912642/
https://ncbi.nlm.nih.gov/pubmed/27306323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11798
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