Survival of Cancer Stem Cells under Hypoxia and Serum Depletion via Decrease in PP2A Activity and Activation of p38-MAPKAPK2-Hsp27

Hypoxia and serum depletion are common features of solid tumors that occur upon antiangiogenesis, irradiation and chemotherapy across a wide variety of malignancies. Here we show that tumor cells expressing CD133, a marker for colorectal cancer initiating or stem cells, are enriched and survive unde...

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Bibliografiske detaljer
Main Authors: Lin, Shih-Pei, Lee, Yi-Ting, Wang, Jir-You, Miller, Stephanie A., Chiou, Shih-Hwa, Hung, Mien-Chie, Hung, Shih-Chieh
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3502468/
https://ncbi.nlm.nih.gov/pubmed/23185379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049605
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