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Structure of the exportin Xpo4 in complex with RanGTP and the hypusine-containing translation factor eIF5A
Xpo4 is a bidirectional nuclear transport receptor that mediates nuclear export of eIF5A and Smad3 as well as import of Sox2 and SRY. How Xpo4 recognizes such a variety of cargoes is as yet unknown. Here we present the crystal structure of the RanGTP·Xpo4·eIF5A export complex at 3.2 Å resolution. Xp...
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| Veröffentlicht in: | Nat Commun |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4912631/ https://ncbi.nlm.nih.gov/pubmed/27306458 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11952 |
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