ppGpp binding to a site at the RNAP-DksA interface accounts for its dramatic effects on transcription initiation during the stringent response

Throughout the bacterial domain, the alarmone ppGpp dramatically reprograms transcription following nutrient limitation. This “stringent response” is critical for survival and antibiotic-tolerance and is a model for transcriptional regulation by small ligands. We report that ppGpp binds to two disti...

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Publicado en:Mol Cell
Main Authors: Ross, Wilma, Sanchez-Vazquez, Patricia, Chen, Albert Y., Lee, Jeong-Hyun, Burgos, Hector L., Gourse, Richard L.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4912440/
https://ncbi.nlm.nih.gov/pubmed/27237053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.04.029
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