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ppGpp binding to a site at the RNAP-DksA interface accounts for its dramatic effects on transcription initiation during the stringent response
Throughout the bacterial domain, the alarmone ppGpp dramatically reprograms transcription following nutrient limitation. This “stringent response” is critical for survival and antibiotic-tolerance and is a model for transcriptional regulation by small ligands. We report that ppGpp binds to two disti...
Shranjeno v:
| izdano v: | Mol Cell |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2016
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4912440/ https://ncbi.nlm.nih.gov/pubmed/27237053 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.04.029 |
| Oznake: |
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