Krüppel-like Factor 4 Modulates Development of BMI1(+) Intestinal Stem Cell-Derived Lineage Following γ-Radiation-Induced Gut Injury in Mice

In response to ionizing radiation-induced injury, the normally quiescent intestinal stem cells marked by BMI1 participate in the regenerative response. Previously, we established a protective role for Krüppel-like factor 4 (KLF4) in the intestinal epithelium where it reduces senescence, apoptosis, a...

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Pubblicato in:Stem Cell Reports
Autori principali: Kuruvilla, Jes G., Kim, Chang-Kyung, Ghaleb, Amr M., Bialkowska, Agnieszka B., Kuo, Calvin J., Yang, Vincent W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2016
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Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4911500/
https://ncbi.nlm.nih.gov/pubmed/27237377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2016.04.014
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