Systematic Identification of Anti-Fungal Drug Targets by a Metabolic Network Approach

New antimycotic drugs are challenging to find, as potential target proteins may have close human orthologs. We here focus on identifying metabolic targets that are critical for fungal growth and have minimal similarity to targets among human proteins. We compare and combine here: (I) direct metaboli...

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Bibliografiske detaljer
Udgivet i:Front Mol Biosci
Main Authors: Kaltdorf, Martin, Srivastava, Mugdha, Gupta, Shishir K., Liang, Chunguang, Binder, Jasmin, Dietl, Anna-Maria, Meir, Zohar, Haas, Hubertus, Osherov, Nir, Krappmann, Sven, Dandekar, Thomas
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2016
Fag:
Molecular Biosciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4911368/
https://ncbi.nlm.nih.gov/pubmed/27379244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2016.00022
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