Systematic Identification of Anti-Fungal Drug Targets by a Metabolic Network Approach

New antimycotic drugs are challenging to find, as potential target proteins may have close human orthologs. We here focus on identifying metabolic targets that are critical for fungal growth and have minimal similarity to targets among human proteins. We compare and combine here: (I) direct metaboli...

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Vydáno v:Front Mol Biosci
Hlavní autoři: Kaltdorf, Martin, Srivastava, Mugdha, Gupta, Shishir K., Liang, Chunguang, Binder, Jasmin, Dietl, Anna-Maria, Meir, Zohar, Haas, Hubertus, Osherov, Nir, Krappmann, Sven, Dandekar, Thomas
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2016
Témata:
Molecular Biosciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4911368/
https://ncbi.nlm.nih.gov/pubmed/27379244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2016.00022
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