Phase I Study of Veliparib (ABT-888) Combined with Cisplatin and Vinorelbine in Advanced Triple-Negative Breast Cancer and/or BRCA Mutation-Associated Breast Cancer

PURPOSE: Cisplatin is synergistic with vinorelbine and the poly(ADP-ribose) polymerase (PARP) inhibitor veliparib, and has anti-neoplastic activity in TNBC and BRCA mutation-associated breast cancer. This phase I study assessed veliparib with cisplatin and vinorelbine. PATIENTS AND METHODS: A 3+3 do...

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Udgivet i:Clin Cancer Res
Main Authors: Rodler, Eve T., Kurland, Brenda F., Griffin, Melissa, Gralow, Julie R., Porter, Peggy, Yeh, Rosa F., Gadi, Vijayakrishna K., Guenthoer, Jamie, Beumer, Jan H., Korde, Larissa, Strychor, Sandra, Kiesel, Brian F., Linden, Hannah M., Thompson, John A., Swisher, Elizabeth, Chai, Xiaoyu, Shepherd, Stacie, Giranda, Vincent, Specht, Jennifer M.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4911292/
https://ncbi.nlm.nih.gov/pubmed/26801247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-2137
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