HLA class II genes modulate vaccine-induced antibody responses to affect HIV-1 acquisition

In the RV144 vaccine trial, two antibody responses were found to correlate with HIV-1 acquisition. Because human leukocyte antigen (HLA) class II–restricted CD4(+) T cells are involved in antibody production, we tested whether HLA class II genotypes affected HIV-1–specific antibody levels and HIV-1...

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Publicado no:Sci Transl Med
Main Authors: Prentice, Heather A., Tomaras, Georgia D., Geraghty, Daniel E., Apps, Richard, Fong, Youyi, Ehrenberg, Philip K., Rolland, Morgane, Kijak, Gustavo H., Krebs, Shelly J., Nelson, Wyatt, DeCamp, Allan, Shen, Xiaoying, Yates, Nicole L., Zolla-Pazner, Susan, Nitayaphan, Sorachai, Rerks-Ngarm, Supachai, Kaewkungwal, Jaranit, Pitisuttithum, Punnee, Ferrari, Guido, Juliana McElrath, M., Montefiori, David C., Bailer, Robert T., Koup, Richard A., O’Connell, Robert J., Robb, Merlin L., Michael, Nelson L., Gilbert, Peter B., Kim, Jerome H., Thomas, Rasmi
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4911012/
https://ncbi.nlm.nih.gov/pubmed/26180102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aab4005
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