IFN-γ–Producing T-Helper 17.1 Cells Are Increased in Sarcoidosis and Are More Prevalent than T-Helper Type 1 Cells

Rationale: Pulmonary sarcoidosis is classically defined by T-helper (Th) cell type 1 inflammation (e.g., IFN-γ production by CD4(+) effector T cells). Recently, IL-17A–secreting cells have been found in lung lavage, invoking Th17 immunity in sarcoidosis. Studies also identified IL-17A–secreting cell...

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Détails bibliographiques
Publié dans:Am J Respir Crit Care Med
Auteurs principaux: Ramstein, Joris, Broos, Caroline E., Simpson, Laura J., Ansel, K. Mark, Sun, Sara A., Ho, Melissa E., Woodruff, Prescott G., Bhakta, Nirav R., Christian, Laura, Nguyen, Christine P., Antalek, Bobby J., Benn, Bryan S., Hendriks, Rudi W., van den Blink, Bernt, Kool, Mirjam, Koth, Laura L.
Format: Artigo
Langue:Inglês
Publié: American Thoracic Society 2016
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Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4910899/
https://ncbi.nlm.nih.gov/pubmed/26649486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201507-1499OC
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