IFN-γ–Producing T-Helper 17.1 Cells Are Increased in Sarcoidosis and Are More Prevalent than T-Helper Type 1 Cells

Rationale: Pulmonary sarcoidosis is classically defined by T-helper (Th) cell type 1 inflammation (e.g., IFN-γ production by CD4(+) effector T cells). Recently, IL-17A–secreting cells have been found in lung lavage, invoking Th17 immunity in sarcoidosis. Studies also identified IL-17A–secreting cell...

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Detalhes bibliográficos
Publicado no:Am J Respir Crit Care Med
Main Authors: Ramstein, Joris, Broos, Caroline E., Simpson, Laura J., Ansel, K. Mark, Sun, Sara A., Ho, Melissa E., Woodruff, Prescott G., Bhakta, Nirav R., Christian, Laura, Nguyen, Christine P., Antalek, Bobby J., Benn, Bryan S., Hendriks, Rudi W., van den Blink, Bernt, Kool, Mirjam, Koth, Laura L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4910899/
https://ncbi.nlm.nih.gov/pubmed/26649486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201507-1499OC
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