IFN-γ–Producing T-Helper 17.1 Cells Are Increased in Sarcoidosis and Are More Prevalent than T-Helper Type 1 Cells

Rationale: Pulmonary sarcoidosis is classically defined by T-helper (Th) cell type 1 inflammation (e.g., IFN-γ production by CD4(+) effector T cells). Recently, IL-17A–secreting cells have been found in lung lavage, invoking Th17 immunity in sarcoidosis. Studies also identified IL-17A–secreting cell...

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Bibliographic Details
Published in:Am J Respir Crit Care Med
Main Authors: Ramstein, Joris, Broos, Caroline E., Simpson, Laura J., Ansel, K. Mark, Sun, Sara A., Ho, Melissa E., Woodruff, Prescott G., Bhakta, Nirav R., Christian, Laura, Nguyen, Christine P., Antalek, Bobby J., Benn, Bryan S., Hendriks, Rudi W., van den Blink, Bernt, Kool, Mirjam, Koth, Laura L.
Format: Artigo
Language:Inglês
Published: American Thoracic Society 2016
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4910899/
https://ncbi.nlm.nih.gov/pubmed/26649486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201507-1499OC
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