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A novel approach of longitudinal adverse event evaluation in oncology clinical trials: the Toxicity over Time (ToxT) analysis of clinical trials N9741 and 979254 (Alliance)

BACKGROUND: Traditional methods of reporting adverse events (AEs) in clinical trials are inadequate for modern oncology therapies with chronic administration. Conventional analysis and display of maximum grade AEs do not capture toxicity profiles that evolve over time or longer lasting, lower grade...

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Detalhes bibliográficos
Publicado no:Lancet Oncol
Main Authors: Thanarajasingam, Gita, Atherton, Pamela J., Novotny, Paul J., Loprinzi, Charles L., Sloan, Jeff A., Grothey, Axel
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4910515/
https://ncbi.nlm.nih.gov/pubmed/27083333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1470-2045(16)00038-3
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