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A fully human IgG1 anti-PD-L1 MAb in an in vitro assay enhances antigen-specific T-cell responses

Monoclonal antibodies (MAbs) that interfere with checkpoint molecules are being investigated for the treatment of infectious diseases and cancer, with the aim of enhancing the function of an impaired immune system. Avelumab (MSB0010718C) is a fully human IgG1 MAb targeting programmed death-ligand 1...

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Foilsithe in:Clin Transl Immunology
Main Authors: Grenga, Italia, Donahue, Renee N, Lepone, Lauren M, Richards, Jacob, Schlom, Jeffrey
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2016
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4910121/
https://ncbi.nlm.nih.gov/pubmed/27350882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cti.2016.27
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