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58-F, a flavanone from Ophiopogon japonicus, prevents hepatocyte death by decreasing lysosomal membrane permeability

Lysosome membrane permeabilization (LMP) has been implicated in cell death. In the present study, we investigated the relationship between cell death and H(2)O(2)-/CCl(4)-induced LMP in hepatocytes in vitro and following acute liver injury in vivo. The key finding was that H(2)O(2) triggered LMP by...

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Bibliografiska uppgifter
I publikationen:Sci Rep
Huvudupphovsmän: Yan, Xiaofeng, Ye, Tingjie, Hu, Xudong, Zhao, Pei, Wang, Xiaoling
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2016
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4910050/
https://ncbi.nlm.nih.gov/pubmed/27306715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27875
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