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Lipidomics profile of a NAPE-PLD KO mouse provides evidence of a broader role of this enzyme in lipid metabolism in the brain

A leading hypothesis of N-acyl ethanolamine (NAE) biosynthesis, including the endogenous cannabinoid anandamide (AEA), is that it depends on hydrolysis of N-acyl-phosphatidylethanolamines (NAPE) by a NAPE-specific phospholipase D (NAPE-PLD). Thus, deletion of NAPE-PLD should attenuate NAE levels. Pr...

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Detaylı Bibliyografya
Yayımlandı:Biochim Biophys Acta
Asıl Yazarlar: Leishman, Emma, Mackie, Ken, Luquet, Serge, Bradshaw, Heather B
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4909477/
https://ncbi.nlm.nih.gov/pubmed/26956082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbalip.2016.03.003
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