Lipidomics profile of a NAPE-PLD KO mouse provides evidence of a broader role of this enzyme in lipid metabolism in the brain

A leading hypothesis of N-acyl ethanolamine (NAE) biosynthesis, including the endogenous cannabinoid anandamide (AEA), is that it depends on hydrolysis of N-acyl-phosphatidylethanolamines (NAPE) by a NAPE-specific phospholipase D (NAPE-PLD). Thus, deletion of NAPE-PLD should attenuate NAE levels. Pr...

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發表在:Biochim Biophys Acta
Main Authors: Leishman, Emma, Mackie, Ken, Luquet, Serge, Bradshaw, Heather B
格式: Artigo
語言:Inglês
出版: 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4909477/
https://ncbi.nlm.nih.gov/pubmed/26956082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbalip.2016.03.003
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