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The mevalonate pathway as a metabolic requirement for autophagy–implications for growth control, proteostasis, and disease
Autophagy is responsible for the degradation and recycling of cellular proteins and organelles. Our recent work shows that the mevalonate pathway influences cell size, growth, and proteostasis by regulating basal autophagic flux through geranylgeranylation of the small GTPase RAB11. The control of a...
Gespeichert in:
| Veröffentlicht in: | Mol Cell Oncol |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Taylor & Francis
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4909433/ https://ncbi.nlm.nih.gov/pubmed/27314093 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2016.1143546 |
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