Retinal degeneration is rescued in transgenic rd mice by expression of the cGMP phosphodiesterase beta subunit.

The beta subunit of the cGMP phosphodiesterase (PDE) gene has been identified as the candidate gene for retinal degeneration in the rd mouse. To study the molecular mechanisms underlying degeneration and the potential for gene repair, we have expressed a functional bovine cGMP PDE beta subunit in tr...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Lem, J, Flannery, J G, Li, T, Applebury, M L, Farber, D B, Simon, M I
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1992
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC49094/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1350091/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.10.4422
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