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Contrasting Frequencies and Effects of cis- and trans-Regulatory Mutations Affecting Gene Expression

Heritable differences in gene expression are caused by mutations in DNA sequences encoding cis-regulatory elements and trans-regulatory factors. These two classes of regulatory change differ in their relative contributions to expression differences in natural populations because of the combined effe...

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Detalhes bibliográficos
Publicado no:Mol Biol Evol
Main Authors: Metzger, Brian P. H., Duveau, Fabien, Yuan, David C., Tryban, Stephen, Yang, Bing, Wittkopp, Patricia J.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4909133/
https://ncbi.nlm.nih.gov/pubmed/26782996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msw011
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