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2',5'-Bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''- oxathiole-2'',2'-dioxide)pyrimidine (TSAO) nucleoside analogues: highlyselective inhibitors of human immunodeficiency virus type 1 that are targeted at the viral reverse transcriptase.

A series of pyrimidine nucleoside analogues containing [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino- 1'',2''-oxathiole-2'',2''-dioxide)]-beta-D-ribofuranose as the pentose were found to inhibit human immunodeficiency virus type 1 [HIV-1(IIIB)] replication at a concentration of 0.06...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Balzarini, J, Pérez-Pérez, M J, San-Félix, A, Schols, D, Perno, C F, Vandamme, A M, Camarasa, M J, De Clercq, E
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1992
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC49088/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1374900/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.10.4392
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