Requirements for Nitric Oxide Generation from Isoniazid Activation In Vitro and Inhibition of Mycobacterial Respiration In Vivo

Isoniazid (INH), a front-line antituberculosis agent, is activated by mycobacterial catalase-peroxidase KatG, converting INH into bactericidal reactive species. Here we investigated the requirements and the pathway of nitric oxide (NO ˙) generation during oxidative activation of INH by Mycobacterium...

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Veröffentlicht in:J Bacteriol
Hauptverfasser: Timmins, Graham S., Master, Sharon, Rusnak, Frank, Deretic, Vojo
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2004
Schlagworte:
Molecular Biology of Pathogens
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC490879/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15292144/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JB.186.16.5427-5431.2004
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