Rapid Discovery of Functional Small Molecule Ligands against Proteomic Targets through Library-Against-Library Screening

[Image: see text] Identifying “druggable” targets and their corresponding therapeutic agents are two fundamental challenges in drug discovery research. The one-bead-one-compound (OBOC) combinatorial library method has been developed to discover peptides or small molecules that bind to a specific tar...

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Vydáno v:ACS Comb Sci
Hlavní autoři: Wu, Chun-Yi, Wang, Don-Hong, Wang, Xiaobing, Dixon, Seth M., Meng, Liping, Ahadi, Sara, Enter, Daniel H., Chen, Chao-Yu, Kato, Jason, Leon, Leonardo J., Ramirez, Laura M., Maeda, Yoshiko, Reis, Carolina F., Ribeiro, Brianna, Weems, Brittany, Kung, Hsing-Jien, Lam, Kit S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2016
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4908505/
https://ncbi.nlm.nih.gov/pubmed/27053324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscombsci.5b00194
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