Functional Characterization of a Small-Molecule Inhibitor of the DKK1-LRP6 Interaction

Background. DKK1 antagonizes canonical Wnt signalling through high-affinity binding to LRP5/6, an essential component of the Wnt receptor complex responsible for mediating downstream canonical Wnt signalling. DKK1 overexpression is known for its pathological implications in osteoporosis, cancer, and...

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Detalhes bibliográficos
Publicado no:ISRN Mol Biol
Main Authors: Iozzi, Sara, Remelli, Rosaria, Lelli, Barbara, Diamanti, Daniela, Pileri, Silvia, Bracci, Luisa, Roncarati, Renza, Caricasole, Andrea, Bernocco, Simonetta
Formato: Artigo
Idioma:Inglês
Publicado em: International Scholarly Research Network 2012
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4908242/
https://ncbi.nlm.nih.gov/pubmed/27398238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5402/2012/823875
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