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The acute and long‐term L‐DOPA effects are independent from changes in the activity of dorsal raphe serotonergic neurons in 6‐OHDA lesioned rats

BACKGROUND AND PURPOSE: L‐DOPA is still the most efficacious pharmacological treatment for Parkinson's disease. However, in the majority of patients receiving long‐term therapy with L‐DOPA, its efficacy is compromised by motor complications, notably L‐DOPA‐induced dyskinesia. Evidence suggests...

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Publicat a:Br J Pharmacol
Autors principals: Miguelez, C, Navailles, S, De Deurwaerdère, P, Ugedo, L
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4908202/
https://ncbi.nlm.nih.gov/pubmed/26805402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13447
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