Hypoxia-induced autophagy as an additional mechanism in human osteosarcoma radioresistance

Osteosarcoma (OS) responds poorly to radiotherapy, but the mechanism is unclear. We found OS tumor tissues expressed high level of protein HIF-1α, a common biological marker indicative of hypoxia. It is known that hypoxic cells are generally radioresistant because of reduced production of irradiatio...

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Detalhes bibliográficos
Publicado no:J Bone Oncol
Main Authors: Feng, Helin, Wang, Jin, Chen, Wei, Shan, Baoen, Guo, Yin, Xu, Jianfa, Wang, Ling, Guo, Peng, Zhang, Yingze
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4908188/
https://ncbi.nlm.nih.gov/pubmed/27335774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbo.2016.03.001
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