p62, upregulated during preneoplasia, induces hepatocellular carcinogenesis by maintaining survival of stressed HCC-initiating cells

p62 is a ubiquitin-binding autophagy receptor and signaling protein that accumulates in premalignant liver diseases and most hepatocellular carcinomas (HCC). Although p62 was proposed to participate in formation of benign adenomas in autophagy-deficient livers, its role in HCC initiation was not exp...

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Publicado en:Cancer Cell
Autores principales: Umemura, Atsushi, He, Feng, Taniguchi, Koji, Nakagawa, Hayato, Yamachika, Shinichiro, Font-Burgada, Joan, Zhong, Zhenyu, Subramaniam, Shankar, Raghunandan, Sindhu, Duran, Angeles, Linares, Juan F, Reina-Campos, Miguel, Umemura, Shiori, Valasek, Mark A., Seki, Ekihiro, Yamaguchi, Kanji, Koike, Kazuhiko, Itoh, Yoshito, Diaz-Meco, Maria T., Moscat, Jorge, Karin, Michael
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4907799/
https://ncbi.nlm.nih.gov/pubmed/27211490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.04.006
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