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Two-way communication between SecY and SecA suggests a Brownian ratchet mechanism for protein translocation

The essential process of protein secretion is achieved by the ubiquitous Sec machinery. In prokaryotes, the drive for translocation comes from ATP hydrolysis by the cytosolic motor-protein SecA, in concert with the proton motive force (PMF). However, the mechanism through which ATP hydrolysis by Sec...

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Pubblicato in:eLife
Autori principali: Allen, William John, Corey, Robin Adam, Oatley, Peter, Sessions, Richard Barry, Baldwin, Steve A, Radford, Sheena E, Tuma, Roman, Collinson, Ian
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4907695/
https://ncbi.nlm.nih.gov/pubmed/27183269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.15598
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