Two-way communication between SecY and SecA suggests a Brownian ratchet mechanism for protein translocation

The essential process of protein secretion is achieved by the ubiquitous Sec machinery. In prokaryotes, the drive for translocation comes from ATP hydrolysis by the cytosolic motor-protein SecA, in concert with the proton motive force (PMF). However, the mechanism through which ATP hydrolysis by Sec...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Allen, William John, Corey, Robin Adam, Oatley, Peter, Sessions, Richard Barry, Baldwin, Steve A, Radford, Sheena E, Tuma, Roman, Collinson, Ian
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Biochemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4907695/
https://ncbi.nlm.nih.gov/pubmed/27183269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.15598
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