Two-way communication between SecY and SecA suggests a Brownian ratchet mechanism for protein translocation

The essential process of protein secretion is achieved by the ubiquitous Sec machinery. In prokaryotes, the drive for translocation comes from ATP hydrolysis by the cytosolic motor-protein SecA, in concert with the proton motive force (PMF). However, the mechanism through which ATP hydrolysis by Sec...

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Bibliographic Details
Published in:eLife
Main Authors: Allen, William John, Corey, Robin Adam, Oatley, Peter, Sessions, Richard Barry, Baldwin, Steve A, Radford, Sheena E, Tuma, Roman, Collinson, Ian
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2016
Subjects:
Biochemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4907695/
https://ncbi.nlm.nih.gov/pubmed/27183269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.15598
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