Erythropoietin Slows Photoreceptor Cell Death in a Mouse Model of Autosomal Dominant Retinitis Pigmentosa

PURPOSE: To test the efficacy of systemic gene delivery of a mutant form of erythropoietin (EPO-R76E) that has attenuated erythropoietic activity, in a mouse model of autosomal dominant retinitis pigmentosa. METHODS: Ten-day old mice carrying one copy of human rhodopsin with the P23H mutation and bo...

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Bibliographic Details
Published in:PLoS One
Main Authors: Rex, Tonia S., Kasmala, Lorraine, Bond, Wesley S., de Lucas Cerrillo, Ana M., Wynn, Kristi, Lewin, Alfred S.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4907422/
https://ncbi.nlm.nih.gov/pubmed/27299810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0157411
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