The non-homologous end-joining pathway of S. cerevisiae works effectively in G1-phase cells, and religates cognate ends correctly and non-randomly

DNA double-strand breaks (DSBs) are potentially lethal lesions repaired by two major pathways: homologous recombination (HR) and non-homologous end-joining (NHEJ). Homologous recombination preferentially reunites cognate broken ends. In contrast, non-homologous end-joining could ligate together any...

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Bibliographic Details
Published in:DNA Repair (Amst)
Main Authors: Gao, Shujuan, Honey, Sangeet, Futcher, Bruce, Grollman, Arthur P.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4907342/
https://ncbi.nlm.nih.gov/pubmed/27130982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2016.03.013
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