SURVIVAL ADVANTAGE COMBINING A BRAF INHIBITOR AND RADIATION IN BRAF V600E-MUTANT GLIOMA

PURPOSE: Radiation (RT) is critical to the treatment of high-grade gliomas (HGGs) but cures remain elusive. The BRAF mutation V600E is critical to the pathogenesis of 10–20% of pediatric gliomas, and a small proportion of adult HGGs. Here we aim to determine whether PLX4720, a specific BRAF V600E in...

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Gepubliceerd in:J Neurooncol
Hoofdauteurs: Dasgupta, Tina, Olow, Aleksandra K., Yang, Xiaodong, Hashizume, Rintaro, Tom, Maxwell, Aoki, Yasuyuki, Berger, Mitchel S., Weiss, William A., Stalpers, Lukas J. A., Prados, Michael, James, C. David, Mueller, Sabine, Haas-Kogan, Daphne A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4907264/
https://ncbi.nlm.nih.gov/pubmed/26384810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-015-1939-2
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