Evolution of Neuroadaptation in the Periphery and Purifying Selection in the Brain Contribute to Compartmentalization of Simian Immunodeficiency Virus (SIV) in the Brains of Rhesus Macaques with SIV-Associated Encephalitis

The emergence of a distinct subpopulation of human or simian immunodeficiency virus (HIV/SIV) sequences within the brain (compartmentalization) during infection is hypothesized to be linked to AIDS-related central nervous system (CNS) neuropathology. However, the exact evolutionary mechanism respons...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Rife, Brittany D., Nolan, David J., Lamers, Susanna L., Autissier, Patrick, Burdo, Tricia, Williams, Kenneth C., Salemi, Marco
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Genetic Diversity and Evolution
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4907235/
https://ncbi.nlm.nih.gov/pubmed/27122578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00137-16
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