Sex and Immunogen-Specific Benefits of Immunotherapy Targeting Islet Amyloid Polypeptide in Transgenic and Wild-Type Mice

Type 2 diabetes mellitus is characterized by the deposition of islet amyloid polypeptide (IAPP) as amyloid in islets, a process thought to be toxic to β-cells. To determine the feasibility of targeting these aggregates therapeutically, we vaccinated transgenic (Tg) mice that overexpress human IAPP a...

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Udgivet i:Front Endocrinol (Lausanne)
Main Authors: Krishnamurthy, Pavan K., Rajamohamedsait, Hameetha B., Gonzalez, Veronica, Rajamohamedsait, Wajitha J., Ahmed, Nawal, Krishnaswamy, Senthilkumar, Sigurdsson, Einar M.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2016
Fag:
Endocrinology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4907063/
https://ncbi.nlm.nih.gov/pubmed/27379014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fendo.2016.00062
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