The Hemogenic Competence of Endothelial Progenitors Is Restricted by Runx1 Silencing during Embryonic Development

It is now well-established that hematopoietic stem cells (HSCs) and progenitor cells originate from a specialized subset of endothelium, termed hemogenic endothelium (HE), via an endothelial-to-hematopoietic transition. However, the molecular mechanisms determining which endothelial progenitors poss...

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Udgivet i:Cell Rep
Main Authors: Eliades, Alexia, Wareing, Sarah, Marinopoulou, Elli, Fadlullah, Muhammad Z.H., Patel, Rahima, Grabarek, Joanna B., Plusa, Berenika, Lacaud, Georges, Kouskoff, Valerie
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2016
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4906370/
https://ncbi.nlm.nih.gov/pubmed/27239041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.05.001
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