GCN2 contributes to mTORC1 inhibition by leucine deprivation through an ATF4 independent mechanism

It is well known that the GCN2 and mTORC1 signaling pathways are regulated by amino acids and share common functions, in particular the control of translation. The regulation of GCN2 activity by amino acid availability relies on the capacity of GCN2 to sense the increased levels of uncharged tRNAs u...

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Vydáno v:Sci Rep
Hlavní autoři: Averous, Julien, Lambert-Langlais, Sarah, Mesclon, Florent, Carraro, Valérie, Parry, Laurent, Jousse, Céline, Bruhat, Alain, Maurin, Anne-Catherine, Pierre, Philippe, Proud, Christopher G., Fafournoux, Pierre
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4906353/
https://ncbi.nlm.nih.gov/pubmed/27297692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27698
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