Amicoumacin A induces cancer cell death by targeting the eukaryotic ribosome

Amicoumacin A is an antibiotic that was recently shown to target bacterial ribosomes. It affects translocation and provides an additional contact interface between the ribosomal RNA and mRNA. The binding site of amicoumacin A is formed by universally conserved nucleotides of rRNA. In this work, we s...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Prokhorova, Irina V., Akulich, Kseniya A., Makeeva, Desislava S., Osterman, Ilya A., Skvortsov, Dmitry A., Sergiev, Petr V., Dontsova, Olga A., Yusupova, Gulnara, Yusupov, Marat M., Dmitriev, Sergey E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4906347/
https://ncbi.nlm.nih.gov/pubmed/27296282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27720
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