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Optimization of Signal Decomposition Matched Filtering (SDMF) for Improved Detection of Copy-Number Variations

We aim to improve the performance of the previously proposed signal decomposition matched filtering (SDMF) method [26] for the detection of copy-number variations (CNV) in the human genome. Through simulations, we show that the modified SDMF is robust even at high noise levels and outperforms the or...

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Detalhes bibliográficos
Publicado no:IEEE/ACM Trans Comput Biol Bioinform
Main Authors: Stamoulis, Catherine, Betensky, Rebecca A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4905595/
https://ncbi.nlm.nih.gov/pubmed/27295643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1109/TCBB.2015.2448077
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