The Dissection of Expression Quantitative Trait Locus Hotspots

Studies of the genetic loci that contribute to variation in gene expression frequently identify loci with broad effects on gene expression: expression quantitative trait locus hotspots. We describe a set of exploratory graphical methods as well as a formal likelihood-based test for assessing whether...

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Bibliographic Details
Published in:Genetics
Main Authors: Tian, Jianan, Keller, Mark P., Broman, Aimee Teo, Kendziorski, Christina, Yandell, Brian S., Attie, Alan D., Broman, Karl W.
Format: Artigo
Language:Inglês
Published: Genetics Society of America 2016
Subjects:
Investigations
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4905536/
https://ncbi.nlm.nih.gov/pubmed/26837753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.115.183624
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