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Bidirectional interconversion of stem and non-stem cancer cell populations: A reassessment of theoretical models for tumor heterogeneity

Resolving the origin of intratumor heterogeneity has proven to be one of the central challenges in cancer research during recent years. Two theoretical models explaining the emergence of intratumor heterogeneity have come to dominate cancer biology literature: the clonal evolution model and the hier...

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Detalhes bibliográficos
Publicado no:Mol Cell Oncol
Main Authors: van Neerven, Sanne M., Tieken, Mathijs, Vermeulen, Louis, Bijlsma, Maarten F.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4905404/
https://ncbi.nlm.nih.gov/pubmed/27308617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2015.1098791
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