Alternative usage of initiation codons in mRNA encoding the cAMP-responsive-element modulator generates regulators with opposite functions.

The cAMP-responsive-element modulator (CREM) gene encodes both antagonists (CREM alpha/beta/gamma) and an activator (CREM tau) of cAMP-responsive transcription by alternative splicing. In adult mouse brain a predominant 21-kDa protein, not corresponding to any previously characterized transcript, is...

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Bibliographic Details

Published in:	Proc Natl Acad Sci U S A
Main Authors:	Delmas, V, Laoide, B M, Masquilier, D, de Groot, R P, Foulkes, N S, Sassone-Corsi, P
Format:	Artigo
Language:	Inglês
Published:	National Academy of Sciences 1992
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC49054/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1584756/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.10.4226
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