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YAP inhibition blocks uveal melanogenesis driven by GNAQ or GNA11 mutations
Uveal melanoma (UM) is the most common adult intraocular tumor. UM often involves activating mutations in guanine nucleotide binding protein (G protein), q polypeptide (GQ), or G Protein, α 11 (G11). We show that the Yes-associated protein (Yap) inhibitor verteporfin blocks tumor growth of Gq/11-mut...
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| Publicado no: | Mol Cell Oncol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4905245/ https://ncbi.nlm.nih.gov/pubmed/27308390 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/23723548.2014.970957 |
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