Saracatinib as a Metastasis Inhibitor in Metastatic Castration-Resistant Prostate Cancer: A University of Chicago Phase 2 Consortium and DOD/PCF Prostate Cancer Clinical Trials Consortium Study

BACKGROUND: Fyn is a kinase that is upregulated in a subset of metastatic castration-resistant prostate cancer. Saracatinib potently inhibits Fyn activation. We have noted a relationship between Fyn expression and directional motility, a cellular process related to metastasis. As such we hypothesize...

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Detalhes bibliográficos
Publicado no:Prostate
Main Authors: Posadas, Edwin M., Ahmed, Rafi S., Karrison, Theodore, Szmulewitz, Russell Z., O’Donnell, Peter H., Wade, James L., Shen, James, Gururajan, Murali, Sievert, Margarit, Stadler, Walter M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4904773/
https://ncbi.nlm.nih.gov/pubmed/26493492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pros.23119
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