Calcineurin inhibitors cyclosporine A and tacrolimus induce vascular inflammation and endothelial activation through TLR4 signaling

The introduction of the calcineurin inhibitors (CNIs) cyclosporine and tacrolimus greatly reduced the rate of allograft rejection, although their chronic use is marred by a range of side effects, among them vascular toxicity. In transplant patients, it is proved that innate immunity promotes vascula...

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Publicado en:Sci Rep
Autores principales: Rodrigues-Diez, Raquel, González-Guerrero, Cristian, Ocaña-Salceda, Carlos, Rodrigues-Diez, Raúl R., Egido, Jesús, Ortiz, Alberto, Ruiz-Ortega, Marta, Ramos, Adrián M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4904742/
https://ncbi.nlm.nih.gov/pubmed/27295076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27915
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