Calcineurin inhibitors cyclosporine A and tacrolimus induce vascular inflammation and endothelial activation through TLR4 signaling

The introduction of the calcineurin inhibitors (CNIs) cyclosporine and tacrolimus greatly reduced the rate of allograft rejection, although their chronic use is marred by a range of side effects, among them vascular toxicity. In transplant patients, it is proved that innate immunity promotes vascula...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Rodrigues-Diez, Raquel, González-Guerrero, Cristian, Ocaña-Salceda, Carlos, Rodrigues-Diez, Raúl R., Egido, Jesús, Ortiz, Alberto, Ruiz-Ortega, Marta, Ramos, Adrián M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4904742/
https://ncbi.nlm.nih.gov/pubmed/27295076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27915
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