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A molecular determinant of phosphoinositide affinity in mammalian TRPV channels
Phosphatidylinositol 4,5-bisphosphate [PI(4,5)P(2)] is an important cofactor for ion channels. Affinity for this lipid is a major determinant of channel inhibition by depletion of PI(4,5)P(2) upon phospholipase C (PLC) activation. Little is known about what determines PI(4,5)P(2) affinity in mammali...
में बचाया:
| में प्रकाशित: | Sci Rep |
|---|---|
| मुख्य लेखकों: | , , , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Nature Publishing Group
2016
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4904367/ https://ncbi.nlm.nih.gov/pubmed/27291418 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27652 |
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